6 Possible Causes for Endometriosis March 23, 2016 by Marta Ribeiro In Social Clips. 5. Immune system dysfunction Having a weak or dysfunctional immune system may lead to endometriosis. Some women suffering with this disease sometimes show immunologic defects or dysfunctions. This may, or may not be one of the causes of it. Print This Page Pages: 1 2 3 4 5 6